The analysis of the human genome opens up completely new possibilities for diagnosis, treatment, and therapy for patients…
Study by the University of Bonn elucidates important mechanism in the brain Nerve cells can regulate their sensitivity to incoming signals autonomously. A new study led by the University of Bonn has now discovered a mechanism that does just that. The German Center for Neurodegenerative Diseases and the Max Planck Institute for Neurobiology…
as you can already see from our Handbook, there are two questions we get asked frequently: What is a Core Facilitity and what is it good for? By coincidence, the Journal “Forschung&Lehre” asked themselves in the October issue of their journal, how “Forschungswerkzeuge” or Research Infrastructures support science. We provided them an article on how…
Dear all, we are happy to announce our new ThemeNight format. A format jointly organized by the Bonner Forum Biomedizin, the Bonn Technology Campus and the Postdoc-Orga team from the ImmunoSensation Cluster. For those who do not know the Theme Nights yet, the series has and will present current topics in research and the…
Dear colleagues, dear users of the Core Facilities, all of us are aware of the restrictions in our public life that were set up to fight the current challenges of the corona pandemic. And it is time to remind you of the restrictions that we already set up for the core facilities during the first…
Dear users of the Core Facilities, Dear Colleagues, core facilites are a place to share instrumentation, spread information and support scienctists. People have to meet. But in order to fulfill our part in reducing the impact and spread of the novel coronavirus, the core facilities have taken some definite decisions to reduce service and the…
The European Journal of Immunology has published the second edition of the very comprehensive guide to flow cytometry and cell sorting in immunological studies. And we contributed to that edition. Here is the information from the abstract: “These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry…
In 2018 the Flow Cytometry Core Facility was able to acquire five new instruments. A FACSAria Fusion cell sorter, a second LSRFortessa cell analyzer and an ImageStream image cytometer were granted by the DFG through a large device application. (“Forschungsgroßgeräte” nach Art.91b GG) Special thanks goes to the excellence cluster “ImmunoSensation”and to the SFB TR57 . A…
Recent reports suggest that somatic cell-derived induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons largely preserve age-associated traits such as age-specific DNA methylation patterns, transcriptomic aging signatures and nuclear lamina-associated changes. Michael Peitz, manager of the Cell Programming Core Facility, co-directed a study which adressed a key question: Are age-associated epigenetic and transcriptional…
The European Journal of Immunology has published a very comprehensive guide to flow cytometry in it’s October issue in which we were involved. 231 authors: experts in cytometry & immunology 214 pages 54 sections including: ◦ equipment set-up, data acquisition & handling ◦ barcoding, CyTOF, combinatorial & imaging cytometry ◦ complete immune cell cytometric …
Dowling-Degos disease is a hereditary pigmentation disorder that generally progresses harmlessly. However, some of those affected also develop severe skin inflammation. An international team of researchers under the leadership of the University of Bonn has now found a cause for this link. Their knowledge comes thanks to an animal that is known among aquarium owners…
The Journal of Biological Chemistry, 291, 103-109. The mechanisms of NLRP3 activation are still poorly understood. Jonathan Schmid-Burgk and colleagues present new data on the identification of NEK7, which specifically functions upstream of NLRP3 activation. NEK7 was identified in an unbiased genetic screening approach, which employed the CRISPR technology to identify macrophages that were rendered…