The primary cilium constitutes an organelle that orchestrates signal transduction independently from the cell body. Dysregulation of this intricate molecular architecture leads to severe human diseases, commonly referred to as ciliopathies. However, the molecular underpinnings how ciliary signaling orchestrates…
Mechanism identified at University of Bonn alters the coupling of nerve cells The brain has the ability to modify the contacts between neurons. Among other things, that is how it prevents brain activity from getting out of control. Researchers from the University Hospital Bonn, together with a team from Australia, have identified a mechanism that…
Researchers at the Universities of Bonn and Sao Paulo have succeeded in mitigating chronic inflammation in mice using customized “mini-antibodies.” These nanobodies enabled them to dissolve molecular complexes in tissue that normally activate the immune system. The nanobodies produced may in future…
Researchers at the University of Bonn use artificial intelligence to detect rare diseases even more accurately Rare genetic diseases can sometimes be recognized through facial features, such as characteristically shaped brows, nose or cheeks. Researchers at the University of Bonn have now trained software that uses portrait photos to better diagnose such diseases. The improved…
Study of mice by the University of Bonn could enable alternative methods to animal experiments in the medium term Researchers at the University of Bonn have developed a method to generate embryo-like cell complexes from the stem cells of mice. The method provides new insights into embryonic development. In the medium term, it might also…
This cooperation is impaired in mutations that can cause Parkinson’s disease To break down toxic proteins more quickly, immune cells in the brain can join together to form networks when needed. This is shown by a joint study of the University of Bonn, the German Center for Neurodegenerative Diseases (DZNE) and the Institut François Jacob…
Researchers at the University of Bonn investigate the role of the transcription factor for dopamine-producing neurons The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the substantia nigra – a particularly sensitive part of the…
Study by the University of Bonn shows that mutations of the investigated gene manifest in different patterns of inheritance The so-called Plexin-A1 gene seems to play a more extensive role in brain development than previously assumed. This is shown by a current study led by the University Hospital Bonn and the Institute of Anatomy of…
Active ingredient inhibits infection with so-called pseudoviruses in the test tube, as shown by study at the University of Bonn Scientists at the University of Bonn and the caesar research center have isolated a molecule that might open new avenues in the fight against SARS coronavirus 2. The active ingredient binds to the spike protein…
Study in Science: Combination of two molecules simultaneously attacks multiple sites on the surface of the virus An international research team led by the University of Bonn has identified and further developed novel antibody fragments against the SARS coronavirus-2. These “nanobodies” are much smaller than the classic antibodies used to treat US President Donald Trump,…
The European Journal of Immunology has published the second edition of the very comprehensive guide to flow cytometry and cell sorting in immunological studies. And we contributed to that edition. Here is the information from the abstract: “These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry…
Recent reports suggest that somatic cell-derived induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons largely preserve age-associated traits such as age-specific DNA methylation patterns, transcriptomic aging signatures and nuclear lamina-associated changes. Michael Peitz, manager of the Cell Programming Core Facility, co-directed a study which adressed a key question: Are age-associated epigenetic and transcriptional…