Co-Authorships:

2023

Silva Ribeiro, D.J., Yüksel, S., Dolf, A., and Wachten, D. (2024). Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. In Tissue-Resident Macrophages: Methods and Protocols Methods in Molecular Biology., E. Mass, ed. (Springer US), pp. 149–158. 10.1007/978-1-0716-3437-0_10.

2022

Steinhoff, C., Pickarski, N., Litt, T., Hajdas, I., Welte, C., Wurst, P., Kühne, D., Dolf, A., Germer, M., and Kallmeyer, J. (2022). NEW APPROACH TO SEPARATE AND DATE SMALL SPORES AND POLLEN FROM LAKE SEDIMENTS IN SEMI-ARID CLIMATES. Radiocarbon 64, 1191–1207. 10.1017/RDC.2022.34.

2021

Chaudhry, S.R., Kahlert, U.D., Kinfe, T.M., Endl, E., Dolf, A., Niemelä, M., Hänggi, D., and Muhammad, S. (2021). Differential polarization and activation dynamics of systemic T helper cell subsets after aneurysmal subarachnoid hemorrhage (SAH) and during post-SAH complications. Sci Rep 11, 14226.

Schneider, M., Vollmer, L., Potthoff, A.-L., Ravi, V.M., Evert, B.O., Dolf, A., Rahman, M.A., Sarowar, S., Kueckelhaus, J., Will, P., Zurhorst, D., et al. (2021). Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro Oncol 23, 1885–1897.

Schneider, M., Potthoff, A.-L., Evert, B.O., Dicks, M., Ehrentraut, D., Dolf, A., Schmidt, E.N.C., Schäfer, N., Borger, V., Pietsch, T., et al. (2021). Inhibition of Intercellular Cytosolic Traffic via Gap Junctions Reinforces Lomustine-Induced Toxicity in Glioblastoma Independent of MGMT Promoter Methylation Status. Pharmaceuticals (Basel) 14, 195.

2020

Korn, M.F., Stein, R.R., Dolf, A., Shakeri, F., Buness, A., Hilgers, C., Masson, W., Gravius, S., Kohlhof, H., Burger, C., et al. (2020). High-Dimensional Analysis of Immune Cell Composition Predicts Periprosthetic Joint Infections and Dissects Its Pathophysiology. Biomedicines 8, E358.

2019

Potthoff, A.-L., Heiland, D.H., Evert, B.O., Almeida, F.R., Behringer, S.P., Dolf, A., Güresir, Á., Güresir, E., Joseph, K., Pietsch, T., et al. (2019). Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide. Cancers (Basel) 11, E858.

Cossarizza, A., Chang, H.-D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W.W., Aghaeepour, N., Akdis, M., Dolf, A., Wurst, P., Allez, M., et al. (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49, 1457–1973.

Graefe, C., Eichhorn, L., Wurst, P., Kleiner, J., Heine, A., Panetas, I., Abdulla, Z., Hoeft, A., Frede, S., Kurts, C., et al. (2019). Optimized Ki-67 staining in murine cells: a tool to determine cell proliferation. Mol Biol Rep 46, 4631–4643.

2017

Luxen, D., Gielen, G.H., Waha, A., Isselstein, L., Müller, T., Koch, P., Hammes, J., Becker, A., Simon, M., Wurst, P., et al. (2017). MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility. Transl Oncol 10, 70–79.

Cossarizza, A., Chang, H.-D., Radbruch, A., Akdis, M., Andrä, I., Annunziato, F., Bacher, P., Barnaba, V., Battistini, L., Dolf, A., Wurst, P.,  Bauer, W.M., et al. (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol 47, 1584–1797.

Acknowledgements:

2023

Tzaridis, T., Weller, J., Bachurski, D., Shakeri, F., Schaub, C., Hau, P., Buness, A., Schlegel, U., Steinbach, J.-P., Seidel, C., et al. (2023). A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression. International Journal of Cancer 152, 308–319. 10.1002/ijc.34261.

Tsukamoto, Y., Hiono, T., Yamada, S., Matsuno, K., Faist, A., Claff, T., Hou, J., Namasivayam, V., Vom Hemdt, A., Sugimoto, S., et al. (2023). Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science 379, 586–591. 10.1126/science.add0875.

Raabe, J., Kaiser, K.M., ToVinh, M., Finnemann, C., Lutz, P., Hoffmeister, C., Bischoff, J., Goeser, F., Kaczmarek, D.J., Glowka, T.R., et al. (2023). Identification and characterization of a hepatic IL-13–producing ILC3-like population potentially involved in liver fibrosis. Hepatology 78, 787. 10.1097/HEP.0000000000000350.

Klümper, N., Ralser, D.J., Ellinger, J., Roghmann, F., Albrecht, J., Below, E., Alajati, A., Sikic, D., Breyer, J., Bolenz, C., et al. (2023). Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance. Clinical Cancer Research 29, 1496–1505. 10.1158/1078-0432.CCR-22-1764.

Kirchhoff, A., Herzner, A.-M., Urban, C., Piras, A., Düster, R., Wegner, J., Grünewald, A., Schlee-Guimarães, T.M., Ciupka, K., Leka, P., et al. (2023). hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I. Preprint at bioRxiv, 10.1101/2023.06.23.545108 10.1101/2023.06.23.545108.

Jenster, L.-M., Lange, K.-E., Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers, L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., et al. (2023). P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. Journal of Experimental Medicine 220, e20220837. 10.1084/jem.20220837.

Heuser-Loy, C., Baumgart, A.-K., Hackstein, C.-P., Courrèges, C.J.F., Philipp, M.-S., Thaiss, C.A., Holland, T., Evaristo, C., Garbi, N., and Kurts, C. (2023). Conditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. The Journal of Immunology 212, 35–42. 10.4049/jimmunol.2300662.

Hawwari, I., Rossnagel, L., Reyes, N.S.R., Maasewerd, S., Jentzsch, M., Demczuk, A., Teichmann, L.L., Meffert, L., Ribeiro, L.S., Kallabis, S., et al. (2023). Platelet-derived transcription factors license human monocyte inflammation. Preprint at bioRxiv, 10.1101/2022.08.10.503291 10.1101/2022.08.10.503291.

Hackstein, C.-P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Klein, S., Assmus, L.M., Odainic, A., Szlapa, J., et al. (2023). Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. Journal of Hepatology 79, 150–166. 10.1016/j.jhep.2023.02.026.

Funke, K., Einsfelder, U., Hansen, A., Arévalo, L., Schneider, S., Nettersheim, D., Stein, V., and Schorle, H. (2023). Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours. Br J Cancer 128, 2270–2282. 10.1038/s41416-023-02247-5.

Barakat, A.K. (2023). Identification of Pharmacogenomic and Functional Biomarkers for Antidepressant Treatment Outcome in Patients-Derived Lymphoblastoid Cell Lines.

Colón, D.F., Wanderley, C.W., Turato, W.M., Borges, V.F., Franchin, M., Castanheira, F.V.S., Nascimento, D., Prado, D., Haruo Fernandes de Lima, M., Volpon, L.C., et al. Paediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction. British Journal of Pharmacology n/a. 10.1111/bph.16286.

2022

Zietzer, A., Steffen, E., Niepmann, S., Düsing, P., Hosen, M.R., Liu, W., Jamme, P., Al-Kassou, B., Goody, P.R., Zimmer, S., et al. (2022). MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease. Cardiovascular Research 118, 316–333. 10.1093/cvr/cvaa322.
Zietzer, A., Al-Kassou, B., Jamme, P., Rolfes, V., Steffen, E., Bulic, M., Hosen, M.R., Goody, P.R., Tiyerili, V., Zimmer, S., et al. (2022). Large extracellular vesicles in the left atrial appendage in patients with atrial fibrillation—the missing link? Clin Res Cardiol 111, 34–49. 10.1007/s00392-021-01873-4.
ToVinh, M., Hörr, G., Dobrikova, K., Gotter, C., Rommel, C., Hoffmeister, C., Raabe, J., Kaiser, K.M., Finnemann, C., Bischoff, J., et al. (2022). Mitochondrial Dysfunction Contributes to Impaired Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy. The Journal of Infectious Diseases 226, 901–906. 10.1093/infdis/jiac103.
Tamadaho, R.S.E., Ritter, M., Wiszniewsky, A., Arndts, K., Mack, M., Hoerauf, A., and Layland, L.E. (2022). Infection-Derived Monocytic MDSCs Require TGF-β to Suppress Filarial-Specific IFN-γ But Not IL-13 Release by Filarial-Specific CD4+ T Cells In Vitro. Frontiers in Tropical Diseases 2.
Steinhoff, C., Pickarski, N., Litt, T., Hajdas, I., Welte, C., Wurst, P., Kühne, D., Dolf, A., Germer, M., and Kallmeyer, J. (2022). NEW APPROACH TO SEPARATE AND DATE SMALL SPORES AND POLLEN FROM LAKE SEDIMENTS IN SEMI-ARID CLIMATES. Radiocarbon 64, 1191–1207. 10.1017/RDC.2022.34.
Steiner, A., Reygaerts, T., Pontillo, A., Ceccherini, I., Moecking, J., Moghaddas, F., Davidson, S., Caroli, F., Grossi, A., Castro, F.F.M., et al. (2022). Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus. J Clin Immunol 42, 325–335. 10.1007/s10875-021-01175-4.
Schneider, R., Leven, P., Mallesh, S., Breßer, M., Schneider, L., Mazzotta, E., Fadda, P., Glowka, T., Vilz, T.O., Lingohr, P., et al. (2022). IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function. Commun Biol 5, 1–16. 10.1038/s42003-022-03772-4.
Roth, K., Pröll-Cornelissen, M.J., Heuß, E.M., Dauben, C.M., Henne, H., Appel, A.K., Schellander, K., Tholen, E., and Große-Brinkhaus, C. (2022). Genetic parameters of immune traits for Landrace and Large White pig breeds. Journal of Animal Breeding and Genetics 139, 695–709. 10.1111/jbg.12735.
Regt, A.K. de, Anand, K., Ciupka, K., Gatterdam, K., Putschli, B., Fusshöller, D., Hilbig, D., Kirchhoff, A., Hunkler, C., Wolter, S., et al. (2022). A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA. 2022.08.02.502180. 10.1101/2022.08.02.502180.
Mallesh, S., Ten Hove, A.S., Schneider, R., Schneiker, B., Efferz, P., Kalff, J.C., de Jonge, W.J., and Wehner, S. (2022). Sympathetic Innervation Modulates Mucosal Immune Homeostasis and Epithelial Host Defense. Cells 11, 2606. 10.3390/cells11162606.
Lesch, E., Schilling, M.T., Brenner, S., Yang, Y., Gruss, O.J., Knoop, V., and Schallenberg-Rüdinger, M. (2022). Plant mitochondrial RNA editing factors can perform targeted C-to-U editing of nuclear transcripts in human cells. Nucleic Acids Research 50, 9966–9983. 10.1093/nar/gkac752.
Kessler, N., Viehmann, S.F., Krollmann, C., Mai, K., Kirschner, K.M., Luksch, H., Kotagiri, P., Böhner, A.M.C., Huugen, D., de Oliveira Mann, C.C., et al. (2022). Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. Journal of Experimental Medicine 219, e20220759. 10.1084/jem.20220759.
Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., et al. (2022). Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature 609, 801–807. 10.1038/s41586-022-05128-8.
Jenster, L.-M., Lange, K.-E., Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers, L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., et al. (2022). P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. Journal of Experimental Medicine 220, e20220837. 10.1084/jem.20220837.
Hildebrand, S., Ibrahim, M., Schlitzer, A., Maegdefessel, L., Röll, W., and Pfeifer, A. (2022). PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle. Commun Biol 5, 1–12. 10.1038/s42003-022-03140-2.
Hawwari, I., Reyes, N.S.R., Ribeiro, L.S., Demczuk, A., Teichmann, L.L., Meffert, L., Bertheloot, D., and Franklin, B.S. (2022). Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes. 2022.08.10.503291. 10.1101/2022.08.10.503291.
Hackstein, C.-P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Assmus, L.M., Odainic, A., Kessler, N., Klein, S., et al. (2022). Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling. 2022.07.21.501031. 10.1101/2022.07.21.501031.
Funke, K., Düster, R., Wilson, P.D.-G., Arévalo, L., Geyer, M., and Schorle, H. (2022). Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors. Cancers 14, 1690. 10.3390/cancers14071690.
Effern, M., Glodde, N., Bawden, E., Liebing, J., Hinze, D., Tüting, T., Gebhardt, T., and Hölzel, M. (2022). CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models. STAR Protocols 3, 101038. 10.1016/j.xpro.2021.101038.
Dhana, E., Klaus, D., Böhner, A., Schmidt, F., von Vietinghoff, S., Boor, P., Djudjaj, S., and Kurts, C. (2022). Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice. Journal of Immunological Methods 507, 113310. 10.1016/j.jim.2022.113310.
Colon, D.F., Wanderley, C.W., Turato, W.M., Borges, V.F., Franchin, M., Castanheira, F.V.S., Nascimento, D., Prado, D., Lima, M.H.F. de, Volpon, L.C., et al. (2022). IL-33 regulates age-dependency of long-term immune dysfunction induced by sepsis. 2022.01.15.476447. 10.1101/2022.01.15.476447.
Carvalho, E.H. de, Bartok, E., Stölting, H., Bajoghli, B., and Leptin, M. (2022). Revisiting the origin of interleukin 1 (IL-1) based on biological activities of IL-1 in anamniotes and their sub-functionalization in amniotes. 2022.02.15.480490. 10.1101/2022.02.15.480490.
Borsche, Max (2022). Die Rolle von CD8+ Dendritischen Zellen in der Pathogenese der experimentellen zerebralen Malaria.
Bertheloot, D., Wanderley, C.W., Schneider, A.H., Schiffelers, L.D., Wuerth, J.D., Tödtmann, J.M., Maasewerd, S., Hawwari, I., Duthie, F., Rohland, C., et al. (2022). Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo. EMBO Molecular Medicine 14, e15415. 10.15252/emmm.202115415.
Becker-Gotot, J., Meissner, M., Kotov, V., Jurado-Mestre, B., Maione, A., Pannek, A., Albert, T., Flores, C., Schildberg, F.A., Gleeson, P.A., et al. (2022). Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ regulatory T cells. 10.1172/JCI159925.

2021

Steiner, A., Reygaerts, T., Pontillo, A., Ceccherini, I., Moecking, J., Moghaddas, F., Davidson, S., Caroli, F., Grossi, A., Castro, F.F.M., et al. (2021). Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus. J Clin Immunol.

Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E.C., Zarbock, A., Garbi, N., and Topham, D.J. (2021). Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19. Nat Rev Immunol 21, 49–64.

Behrends, J., Schwager, C., Hein, M., Scholzen, T., Kull, S., and Jappe, U. Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation. Allergy n/a.

Böhner, A.M.C., Jacob, A.M., Heuser, C., Stumpf, N.E., Effland, A., Abdullah, Z., Meyer-Schwesiger, C., von Vietinghoff, S., and Kurts, C. (2021). Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice. J Am Soc Nephrol 32, 2445–2453.

Enderes, J., Mallesh, S., Schneider, R., Hupa, K.J., Lysson, M., Schneiker, B., Händler, K., Schlotmann, B., Günther, P., Schultze, J.L., et al. (2021). A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling. Frontiers in Immunology 11, 3448.

Helmstaedter, C., Hansen, N., Leelaarporn, P., Schwing, K., Oender, D., Widman, G., Racz, A., Surges, R., Becker, A., and Witt, J.-A. (2021). Specific B- and T-cell populations are associated with cognition in patients with epilepsy and antibody positive and negative suspected limbic encephalitis. J Neurol 268, 455–466.

Kimura, K., Breitbach, M., Schildberg, F.A., Hesse, M., and Fleischmann, B.K. (2021). Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo. Bone Reports 15, 101133.

Kleiner, J.L., Köpke, O., Faron, A., Zhang, Y., Cornelssen, J., Coburn, M., Frede, S., Eichhorn, L., and Weisheit, C.K. (2021). Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens. Mediators of Inflammation 2021, e1376859.

Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., Raabe, J., Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., et al. (2021). Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity 54, 2650-2669.e14.

Mallesh, S., Schneider, R., Schneiker, B., Lysson, M., Efferz, P., Lin, E., de Jonge, W.J., and Wehner, S. (2021). Sympathetic Denervation Alters the Inflammatory Response of Resident Muscularis Macrophages upon Surgical Trauma and Ameliorates Postoperative Ileus in Mice. International Journal of Molecular Sciences 22, 6872.

Mayr, A., Marciniak, J., Eggers, B., Blawat, K., Wildenhof, J., Bastos Craveiro, R., Wolf, M., Deschner, J., Jäger, A., and Beisel-Memmert, S. (2021). Autophagy Induces Expression of IL-6 in Human Periodontal Ligament Fibroblasts Under Mechanical Load and Overload and Effects Osteoclastogenesis in vitro. Front Physiol 12, 716441.

Meir, M., Kannapin, F., Diefenbacher, M., Ghoreishi, Y., Kollmann, C., Flemming, S., Germer, C.-T., Waschke, J., Leven, P., Schneider, R., et al. (2021). Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent. International Journal of Molecular Sciences 22, 1887.

Muenster, S., Zschernack, V., Dierig, B., Frede, S., Baumgarten, G., Coburn, M., Putensen, C., and Weisheit, C.K. (2021). Vancomycin and daptomycin modulate the innate immune response in a murine model of LPS-induced sepsis. Int J Immunopathol Pharmacol 35, 20587384211031372.

Peng, W., Kwiek, B., Yu, C., Garbi, N., Allam, J.-P., Oldenburg, J., and Novak, N. (2021). Infiltration and Clustering of Major Histocompatibility Complex II+ Antigen-Presenting Cells in the Skin of Patients with Atopic Dermatitis. J Invest Dermatol 141, 939–942.

Pitsch, J., van Loo, K.M.J., Gallus, M., Dik, A., Kamalizade, D., Baumgart, A.-K., Gnatkovsky, V., Müller, J.A., Opitz, T., Hicking, G., et al. (2021). CD8+ T-Lymphocyte-Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy. Ann Neurol 89, 666–685.

Sadeghlar, F., Vogt, A., Mohr, R.U., Mahn, R., van Beekum, K., Kornek, M., Weismüller, T.J., Branchi, V., Matthaei, H., Toma, M., et al. (2021). Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells. Cancer Immunol Immunother 70, 1451–1464.

Scheiblich, H., Dansokho, C., Mercan, D., Schmidt, S.V., Bousset, L., Wischhof, L., Eikens, F., Odainic, A., Spitzer, J., Griep, A., et al. (2021). Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell 184, 5089-5106.e21.

Tzaridis, T., Bachurski, D., Liu, S., Surmann, K., Babatz, F., Gesell Salazar, M., Völker, U., Hallek, M., Herrlinger, U., Vorberg, I., et al. (2021). Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications. International Journal of Molecular Sciences 22, 9211.

Weisheit, C.K., Kleiner, J.L., Rodrigo, M.B., Niepmann, S.T., Zimmer, S., Duerr, G.D., Coburn, M., Kurts, C., Frede, S., and Eichhorn, L. (2021). CX3CR1 is a prerequisite for the development of cardiac hypertrophy and left ventricular dysfunction in mice upon transverse aortic constriction. PLoS One 16, e0243788.

Wu, X., Zhang, Y., Li, Y., and Schmidt-Wolf, I.G.H. (2021). Improvements in Flow Cytometry-Based Cytotoxicity Assay. Cytometry A 99, 680–688.

Zietzer, A., Al-Kassou, B., Jamme, P., Rolfes, V., Steffen, E., Bulic, M., Hosen, M.R., Goody, P.R., Tiyerili, V., Zimmer, S., et al. (2021). Large extracellular vesicles in the left atrial appendage in patients with atrial fibrillation-the missing link? Clin Res Cardiol.(2021).

Reiner Schneider1 , Patrick Leven1, Tim Glowka1, Ivan Kuzmanov1, Mariola Lysson1,Bianca Schneiker1, Anna Miesen1, Younis Baqi2,3, Claudia Spanier3, Iveta Grants4, Elvio Mazzotta4, Egina Villalobos-Hernandez4, Jörg C Kalff1, Christa E Müller3, Fedias L Christofi4 & Sven Wehner1 A novel P2X2-dependent purinergic mechanism of enteric gliosis in intestinal inflammation. EMBO Molecular Medicine 13, e12724.

2020

Aglan, H.S., Gebremedhn, S., Salilew-Wondim, D., Neuhof, C., Tholen, E., Holker, M., Schellander, K., and Tesfaye, D. (2020). Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells. Cell Tissue Res 380, 643–655.

Ataide, M.A., Komander, K., Knöpper, K., Peters, A.E., Wu, H., Eickhoff, S., Gogishvili, T., Weber, J., Grafen, A., Kallies, A., et al. (2020). BATF3 programs CD8+ T cell memory. Nat Immunol 21, 1397–1407.

Blawat, K., Mayr, A., Hardt, M., Kirschneck, C., Nokhbehsaim, M., Behl, C., Deschner, J., Jäger, A., and Memmert, S. (2020). Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts. Int J Mol Sci 21, E9446.

Bonaguro, L., Köhne, M., Schmidleithner, L., Schulte-Schrepping, J., Warnat-Herresthal, S., Horne, A., Kern, P., Günther, P., ter Horst, R., Jaeger, M., et al. (2020). CRELD1 modulates homeostasis of the immune system in mice and humans. Nat Immunol 21, 1517–1527.

Bosso, M., Bozzo, C.P., Hotter, D., Volcic, M., Stürzel, C.M., Rammelt, A., Ni, Y., Urban, S., Becker, M., Schelhaas, M., et al. (2020). Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells. PLOS Pathogens 16, e1008752.

Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H.N., Yong, M., Bawden, E., Hinze, D., van den Boorn-Konijnenberg, D., Daoud, M., et al. (2020). Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity 53, 564-580.e9.

Enders, M., Franken, L., Philipp, M.-S., Kessler, N., Baumgart, A.-K., Eichler, M., Wiertz, E.J.H., Garbi, N., and Kurts, C. (2020). Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections. J Immunol 204, 87–100.

Frohberger, S.J., Fercoq, F., Neumann, A.-L., Surendar, J., Stamminger, W., Ehrens, A., Karunakaran, I., Remion, E., Vogl, T., Hoerauf, A., et al. (2020). S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis. PLOS Neglected Tropical Diseases 14, e0008119.

Gebremedhn, S., Gad, A., Aglan, H.S., Laurincik, J., Prochazka, R., Salilew-Wondim, D., Hoelker, M., Schellander, K., and Tesfaye, D. (2020). Extracellular vesicles shuttle protective messages against heat stress in bovine granulosa cells. Sci Rep 10, 15824.

Haddouti, E.-M., Randau, T.M., Hilgers, C., Masson, W., Walgenbach, K.J., Pflugmacher, R., Burger, C., Gravius, S., and Schildberg, F.A. (2020a). Characterization and Comparison of Human and Ovine Mesenchymal Stromal Cells from Three Corresponding Sources. International Journal of Molecular Sciences 21, 2310.

Haddouti, E.-M., Randau, T.M., Hilgers, C., Masson, W., Pflugmacher, R., Burger, C., Gravius, S., and Schildberg, F.A. (2020b). Vertebral Bone Marrow-Derived Mesenchymal Stromal Cells from Osteoporotic and Healthy Patients Possess Similar Differentiation Properties In Vitro. International Journal of Molecular Sciences 21, 8309.

Hernandez, V., and Maria, A. (2020). Inducing immunity to liver stage malaria through endogenous tissue resident memory cells. Dissertation

Jobin, K., Stumpf, N.E., Schwab, S., Eichler, M., Neubert, P., Rauh, M., Adamowski, M., Babyak, O., Hinze, D., Sivalingam, S., et al. (2020). A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation. Sci Transl Med 12, eaay3850.

Kaiser, F., Kubaczka, C., Graf, M., Langer, N., Langkabel, J., Arévalo, L., and Schorle, H. (2020). Choice of factors and medium impinge on success of ESC to TSC conversion. Placenta 90, 128–137.

Korn, M.F., Stein, R.R., Dolf, A., Shakeri, F., Buness, A., Hilgers, C., Masson, W., Gravius, S., Kohlhof, H., Burger, C., et al. (2020). High-Dimensional Analysis of Immune Cell Composition Predicts Periprosthetic Joint Infections and Dissects Its Pathophysiology. Biomedicines 8, E358.

Kuehlwein, J.M., Borsche, M., Korir, P.J., Risch, F., Mueller, A.-K., Hübner, M.P., Hildner, K., Hoerauf, A., Dunay, I.R., and Schumak, B. (2020). Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation. Immunology 159, 193–204.

Mengoni, M., Braun, A.D., Gaffal, E., and Tüting, T. (2020). The aryl hydrocarbon receptor promotes inflammation-induced dedifferentiation and systemic metastatic spread of melanoma cells. International Journal of Cancer 147, 2902–2913.

Pilsl, S., Morgan, C., Choukeife, M., Möglich, A., and Mayer, G. (2020). Optoribogenetic control of regulatory RNA molecules. Nat Commun 11, 4825.

Rüwald, J.M., Randau, T.M., Hilgers, C., Masson, W., Irsen, S., Eymael, R.L., Kohlhof, H., Gravius, S., Burger, C., Wirtz, D.C., et al. (2020). Extracellular Vesicle Isolation and Characterization from Periprosthetic Joint Synovial Fluid in Revision Total Joint Arthroplasty. J Clin Med 9, E516.

Schulte, R., Wohlleber, D., Unrau, L., Geers, B., Metzger, C., Erhardt, A., Tiegs, G., van Rooijen, N., Heukamp, L.C., Klotz, L., et al. (2020). Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis. International Journal of Molecular Sciences 21, 2523.

Steffen, E., Mayer von Wittgenstein, W.B.E., Hennig, M., Niepmann, S.T., Zietzer, A., Werner, N., Rassaf, T., Nickenig, G., Wassmann, S., Zimmer, S., et al. (2020). Murine sca1/flk1-positive cells are not endothelial progenitor cells, but B2 lymphocytes. Basic Res Cardiol 115, 18.

Walter, S.G., Randau, T.M., Hilgers, C., Haddouti, E.-M., Masson, W., Gravius, S., Burger, C., Wirtz, D.C., and Schildberg, F.A. (2020). Molecular and Functional Phenotypes of Human Bone Marrow-Derived Mesenchymal Stromal Cells Depend on Harvesting Techniques. International Journal of Molecular Sciences 21, 4382.

Zhang, L., Haddouti, E.-M., Beckert, H., Biehl, R., Pariyar, S., Rüwald, J.M., Li, X., Jaenisch, M., Burger, C., Wirtz, D.C., et al. (2020). Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages. Mediators Inflamm 2020, 3824593.

2019

Ehrentraut, H., Weisheit, C.K., Frede, S., and Hilbert, T. (2019). Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation. JoVE (Journal of Visualized Experiments) e59999.

Graefe, C., Eichhorn, L., Wurst, P., Kleiner, J., Heine, A., Panetas, I., Abdulla, Z., Hoeft, A., Frede, S., Kurts, C., et al. (2019). Optimized Ki-67 staining in murine cells: a tool to determine cell proliferation. Mol Biol Rep 46, 4631–4643.

Hupa, K.J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J.C., and Wehner, S. (2019). AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice. Sci Rep 9, 10602.

Passos, V., Zillinger, T., Casartelli, N., Wachs, A.S., Xu, S., Malassa, A., Steppich, K., Schilling, H., Franz, S., Todt, D., et al. Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor. Journal of Virology 93, e01221-19.

Potthoff, A.-L., Heiland, D.H., Evert, B.O., Almeida, F.R., Behringer, S.P., Dolf, A., Güresir, Á., Güresir, E., Joseph, K., Pietsch, T., et al. (2019). Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide. Cancers (Basel) 11, E858.

2018

Breitbach, M., Kimura, K., Luis, T.C., Fuegemann, C.J., Woll, P.S., Hesse, M., Facchini, R., Rieck, S., Jobin, K., Reinhardt, J., et al. (2018). In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche. Cell Stem Cell 22, 262-276.e7.

Gotot, J., Dhana, E., Yagita, H., Kaiser, R., Ludwig-Portugall, I., and Kurts, C. (2018). Antigen-specific Helios−, Neuropilin-1− Tregs induce apoptosis of autoreactive B cells via PD-L1. Immunology & Cell Biology 96, 852–862.

Holland, T., Wohlleber, D., Marx, S., Kreutzberg, T., Vento-Asturias, S., Schmitt-Mbamunyo, C., Welz, M., Janas, M., Komander, K., Eickhoff, S., et al. (2018). Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation. Journal of Allergy and Clinical Immunology 141, 416-419.e10.

Hoß, F. Alternative splicing as a regulatory mechanism of the NLRP3 inflammasome. 141.

Hoss, F., Rolfes, V., Davanso, M.R., Braga, T.T., and Franklin, B.S. (2018). Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking. In Innate Immune Activation: Methods and Protocols, D. De Nardo, and C.M. De Nardo, eds. (New York, NY: Springer), pp. 149–165.

Stein, K., Hieggelke, L., Schneiker, B., Lysson, M., Stoffels, B., Nuding, S., Wehkamp, J., Kikhney, J., Moter, A., Kalff, J.C., et al. (2018a). Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus. PLOS ONE 13, e0195516.

Stein, K., Lysson, M., Schumak, B., Vilz, T., Specht, S., Heesemann, J., Roers, A., Kalff, J.C., and Wehner, S. (2018b). Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus. Frontiers in Immunology 9, 2599.

Tolksdorf, F., Mikulec, J., Geers, B., Endig, J., Sprezyna, P., Heukamp, L.C., Knolle, P.A., Kolanus, W., and Diehl, L. (2018). The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production. Sci Rep 8, 16123.

Wüsten, K.A., Reddy, P.P., Smiyakin, A., Bernis, M.E., and Tamgüney, G. (2018). A Bioluminescent Cell Assay to Quantify Prion Protein Dimerization. Sci Rep 8, 14178.

2017

Engel, C., Brügmann, G., Lambing, S., Mühlenbeck, L.H., Marx, S., Hagen, C., Horváth, D., Goldeck, M., Ludwig, J., Herzner, A.-M., et al. (2017). RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation. Cancer Immunol Res 5, 455–467.

Glodde, N., Bald, T., van den Boorn-Konijnenberg, D., Nakamura, K., O’Donnell, J.S., Szczepanski, S., Brandes, M., Eickhoff, S., Das, I., Shridhar, N., et al. (2017). Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. Immunity 47, 789-802.e9.

Heine, A., Flores, C., Gevensleben, H., Diehl, L., Heikenwalder, M., Ringelhan, M., Janssen, K.-P., Nitsche, U., Garbi, N., Brossart, P., et al. (2017). Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination. OncoImmunology 6, e1338995.

Heuser, C., Gotot, J., Piotrowski, E.C., Philipp, M.-S., Courrèges, C.J.F., Otte, M.S., Guo, L., Schmid-Burgk, J.L., Hornung, V., Heine, A., et al. (2017). Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Reports 21, 578–586.

Jansen, F., Zietzer, A., Stumpf, T., Flender, A., Schmitz, T., Nickenig, G., and Werner, N. (2017). Endothelial microparticle-promoted inhibition of vascular remodeling is abrogated under hyperglycaemic conditions. Journal of Molecular and Cellular Cardiology 112, 91–94.

Krämer, B., Goeser, F., Lutz, P., Glässner, A., Boesecke, C., Schwarze-Zander, C., Kaczmarek, D., Nischalke, H.D., Branchi, V., Manekeller, S., et al. (2017). Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy. PLOS Pathogens 13, e1006373.

Layer, J.P., Kronmüller, M.T., Quast, T., Boorn-Konijnenberg, D. van den, Effern, M., Hinze, D., Althoff, K., Schramm, A., Westermann, F., Peifer, M., et al. (2017). Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. OncoImmunology 6, e1320626.

Coch, C., Stümpel, J.P., Lilien-Waldau, V., Wohlleber, D., Kümmerer, B.M., Bekeredjian-Ding, I., Kochs, G., Garbi, N., Herberhold, S., Schuberth-Wagner, C., et al. (2017). RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. Molecular Therapy 25, 2093–2103.

Li, J., Riedt, T., Goossens, S., Carrillo García, C., Szczepanski, S., Brandes, M., Pieters, T., Dobrosch, L., Gütgemann, I., Farla, N., et al. (2017). The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling. Blood 129, 460–472.

Pohl, J.-M., Gutweiler, S., Thiebes, S., Volke, J.K., Klein-Hitpass, L., Zwanziger, D., Gunzer, M., Jung, S., Agace, W.W., Kurts, C., et al. (2017). Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus. Gut 66, 2110–2120.

Reinhardt, J., Landsberg, J., Schmid-Burgk, J.L., Ramis, B.B., Bald, T., Glodde, N., Lopez-Ramos, D., Young, A., Ngiow, S.F., Nettersheim, D., et al. (2017). MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Cancer Res 77, 4697–4709.

Saeed-Zidane, M., Linden, L., Salilew-Wondim, D., Held, E., Neuhoff, C., Tholen, E., Hoelker, M., Schellander, K., and Tesfaye, D. (2017). Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress. PLOS ONE 12, e0187569.

Stutz, A., Kolbe, C.-C., Stahl, R., Horvath, G.L., Franklin, B.S., van Ray, O., Brinkschulte, R., Geyer, M., Meissner, F., and Latz, E. (2017). NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. Journal of Experimental Medicine 214, 1725–1736.