Nießing, B.*, Breitkreuz, Y.*, Elanzew, A., De Toledo, M.A.S., Vajs, P., Nolden, M., Erkens, F., Wanek, P., Au Yeung, S.W.C., Haupt, S., König, N., Peitz, M., Schmitt, R.H., Zenke, M., Brüstle, O. (2024)
Automated CRISPR/Cas9-based genome editing of human pluripotent stem cells using the StemCellFactory
Front Bioeng Biotechnol. 12:1459273. doi.org/10.3389/fbioe.2024.1459273
de Ohki CM, McNeill RV, Vernon AC, Smedler E, Michel TM, Peitz M, Potier MC, Kittel-Schneider S, Grünblatt E; members of the iPSC Platform for Neuropsychiatry ECNP Network. Correspondence to “Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation” by Hewitt et al. (PMID: 37402854). Mol Psychiatry. 2024 May 24. doi: 10.1038/s41380-024-02602-9.
Haubenreich, C., Lenz, M., Schubert, A., Peitz, M., Koch, P., Zenke, M., Brüstle, O. (2024)
Epigenetic and transcriptional shifts in human neural stem cells after reprogramming into induced pluripotent stem cells and subsequent redifferentiation.
Int. J. Mol. Sci. 25:3214; https://doi.org/10.3390/ijms25063214
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry. 2023 May 3;13(1):143. doi: 10.1038/s41398-023-02432-3 *corresponding authors
Alich, T.C., Röderer, P., Szalontai, B., Golcuk, K., Tariq, S., Peitz, M., Brüstle, O., Mody, I. Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings.
Front. Cell. Neurosci., 2023 Jan 17: Volume 16 – 2022. doi.org/10.3389/fncel.2022.1039957
Wischhof, L., Lee, H.M., Tutas, J., Overkott, C., Tedt, E., Stork, M., Peitz, M., Brüstle, O., Ulas, T., Händler, K., Schultze, J.L., Ehninger, D., Nicotera, P., Salomoni, P., Bano, D. (2022)
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
EMBO J. 2022 Oct 28:e110595. doi: 10.15252/embj.2022110595.
Wen, J., Peitz, M., Brüstle, O. (2022)
A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico.
J Neurosci Methods. 373:109562. doi.org/10.1016/j.jneumeth.2022.109562.
Wolf, C., Pouya, A., Bitar, S., Pfeiffer, A., Bueno, D., Rojas-Charry, L., Arndt, S., Gomez-Zepeda, D., Tenzer, S., Dal Bello, F., Vianello, C., Ritz, S., Schwirz, J., Dobrindt, K., Peitz, M., Hanschmann, E.-M., Mencke, P., Boussaad, I., Silies, M., Brüstle, O., Giacomello, M., Krüger, R., Methner, A. (2022)
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton.
Commun Biol. 5:541. doi.org/10.1038/s42003-022-03487-6
Gather, F., Ihrig-Biedert, I., Kohlhas, P., Krutenko, T., Peitz, M., Brüstle, O., Pautz, A., Kleinert, H. (2022)
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types.
Cell Commun Signal. 20:47. doi: 10.1186/s12964-022-00855-x.
Schmid, B., Holst, B., Clausen, C., Bahnassawy, L., Reinhardt, P., Bakker, M.H.M., Díaz-Guerra, E., Vicario, C., Martino-Adami, P.V., Thoenes, M., Ramirez, A., Flissbach, K., Grezella, C., Brüstle, O., Peitz, M., Ebneth, A., Cabrera-Socorro, A. (2021)
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.
Stem Cell Res. 52:102180. doi: 10.1016/j.scr.2021.102180.
Manstein, F., Ullmann, K., Kropp, C., Halloin, C., Triebert, W., Franke, A., Farr, C.M., Sahabian, A., Haase, A., Breitkreuz, Y., Peitz, M., Brüstle, O., Kalies, S., Martin, U., Olmer, R., Zweigerdt, R. (2021)
High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling.
Stem Cells Transl Med. 10:1063–1080. doi: 10.1002/sctm.20-0453.
Cheffer, A., Flitsch, L.J., Krutenko, T., Röderer, P., Sokhranyaeva, L., Iefremova, V., Hajo, M., Peitz, M., Schwarz, M.K., Brüstle, O. (2020)
Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction.
Molecular Autism 11:99. doi.org/10.1186/s13229-020-00383-w.
Cenini, G., Hebisch, M., Iefremova, V., Flitsch, L.J., Breitkreuz, Y., Tanzi, R.E., Kim, D.Y., Peitz, M., Brüstle, O. (2021)
Dissecting Alzheimer’s disease pathogenesis in human 2D and 3D models.
Mol Cell Neurosci. 110:103568. doi: 10.1016/j.mcn.2020.103568. Review.
Elanzew, A., Nießing, B., Langendoerfer, D., Rippel, O., Piotrowski, T., Schenk, F., Kulik, M., Peitz, M., Breitkreuz, Y., Jung, S., Wanek, P., Stappert, L., Schmitt, R.H., Haupt, S., Zenke, M., König, N., Brüstle, O. (2020)
The StemCellFactory: A modular system integration for automated generation and expansion of human induced pluripotent stem cells.
Front Bioeng Biotechnol. 8:580352. doi: 10.3389/fbioe.2020.580352.
Tabari, D., Scholl, C., Steffens, M., Weickhardt, S., Elgner, F., Bender, D., Herrlein, M.L., Sabino, C., Semkova, V., Peitz, M., Till, A., Brüstle, O., Hildt, E., Stingl, J. (2020)
Impact of Zika virus infection on human neural stem cell microRNA signatures.
Viruses. 12:E1219. doi: 10.3390/v12111219.
Rehbach K, Kesavan J, Hauser S, Ritzenhofen S, Jungverdorben J, Schüle R, Schöls L, Peitz M, Brüstle O. Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. Sci Rep 2019 Jul 3;9(1):9615
Meijer, M.#, Rehbach, K.#, Brunner, J.W., Classen, J.A., Lammertse, H.C.A., van Linge, L.A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L.N., Sullivan, P.F., Peitz, M.*, Toonen, R.F., Brüstle, O.*, Verhage, M.*
A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons.
Cell Reports 2019 May 14;27(7):2199-2211.e6 *corresponding authors
Rhee, H.J.#, Shaib, A.H.#, Rehbach, K.#, Lee, C.K., Seif, P., Thomas, C., Gideons, E., Guenther, A., Krutenko, T., Hebisch, M., Peitz, M., Brose, N., Brüstle, O.*, Rhee, J.S.* (2019)
An autaptic culture system for standardized analyses of iPSC-derived human neurons.
Cell Reports 2019 May 14;27(7):2212-2228.e7
Weykopf, B. , Haupt, S. , Jungverdorben, J. , Flitsch, L. J., Hebisch, M. , Liu, G. , Suzuki, K. , Belmonte, J. C., Peitz, M. , Blaess, S. , Till, A., Brüstle, O. (2019)
Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson’s Disease.
Eur J Neurosci. 2019 Feb;49(4):561-589.
Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, H., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M.*, Brüstle, O.* (2018)
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Nat Commun 2018 Oct 2;9(1):4047.
*corresponding authors
Evert, B.O., Nalavade, R., Jungverdorben, J., Matthes, F., Weber, S., Rajput, A., Bonn, S., Brüstle, O., Peitz, M., Krauß, S. (2018)
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
PLoS One 2018 Aug 7;13(8):e0201794.
Peitz, M., Bechler, T., Thiele, C.C., Veltel, M., Bloschies, M., Fliessbach, K., Ramirez, A., Brüstle, O. (2018)
Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer’s disease patient with APOE ɛ4/ɛ4 genotype.
Stem Cell Res 2018 May;29:250-253.
de Boni, L., Gasparoni, G., Haubenreich, C., Tierling, S., Schmitt, I., Peitz, M., Koch, P., Walter, J., Wüllner, U., Brüstle, O. (2018)
DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.
Clin Epigenetics. 2018 Jan 29;10:13.
Minnerop, M., Kurzwelly, D., Wagner, H., Soehn, A.S., Reichbauer, J., Tao, F., Rattay, T.W., Peitz, M., Rehbach, K., Giorgetti, A., Pyle, A., Thiele, H., Altmüller, J., Timmann, D., Karaca, I., Lennarz, M., Baets, J., Hengel, H., Synofzik, M., Atasu, B., Feely, S., Kennerson, M., Stendel, C., Lindig, T., Gonzalez, M.A., Stirnberg, R., Sturm, M., Roeske, S., Jung, J., Bauer, P., Lohmann, E., Herms, S., Heilmann-Heimbach, S., Nicholson, G., Mahanjah, M., Sharkia, R., Carloni, P., Brüstle, O., Klopstock, T., Mathews, K.D., Shy, M.E., de Jonghe, P., Chinnery, P,F,, Horvath, R., Kohlhase, J., Schmitt, I., Wolf, M., Greschus, S., Amunts, K., Maier, W., Schöls, L., Nürnberg, P., Zuchner, S., Klockgether, T., Ramirez, A., Schüle, R. (2017)
Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.
Brain. 2017 Jun 1;140(6):1561-1578.
De Sousa, P.A., Steeg, R., Wachter, E., Bruce, K., King, J., Hoeve, M., Khadun, S., McConnachie, G., Holder, J., Kurtz, A., Seltmann, S., Dewender, J., Reimann, S., Stacey, G., O’Shea, O., Chapman, C., Healy, L, Zimmermann, H., Bolton, B., Rawat, T., Atkin, I, Veiga, A., Kuebler, B., Serano, B.M., Saric, T., Hescheler, J., Brüstle, O., Peitz, M., Thiele, C., Geijsen, N., Holst, B., Clausen, C., Lako, M., Armstrong, L., Gupta, S.K.,
Kvist, A.J., Hicks, R., Jonebring, A., Brolén, G., Ebneth, A., Cabrera-Socorro, A., Foerch, P., Geraerts, M., Stummann, T.C., Harmon, S., George, C., Streeter, I., Clarke, L., Parkinson, H., Harrison, P.W., Faulconbridge, A., Cherubin, L., Burdett, T., Trigueros, C., Patel, M.J., Lucas, C., Hardy, B., Predan, R., Dokler, J., Brajnik, M., Keminer, O., Pless, O., Gribbon, P., Claussen, C., Ringwald, A., Kreisel, B., Courtney, A., Allsopp, t.E. (2017)
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) – the Hot Start experience.
Stem Cell Research 2017 Apr;20:105-114
Schwenk, B.M., Hartmann, H., Serdaroglu, A., Schludi, MH., Hornburg, D., Meissner, F., Orozco, D., Colombo, A., Tahirovic, S., Michaelsen, M., Schreiber, F., Haupt, S., Peitz, M., Brüstle, O., Küpper, C., Klopstock, T., Otto, M., Ludolph, A.C., Arzberger, T., Kuhn, P.H., Edbauer, D. (2016)
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
EMBO J 2016 Nov 2;35(21):2350-2370.
Roese-Koerner, B., Stappert, L., Berger, T., Braun, N.C., Veltel, M., Jungverdorben, J., Evert, B.O., Peitz, M., Borghese, L., Brüstle, O. (2016)
Reciprocal regulation between bifunctional miR-9/9* and its transcriptional modulator Notch in human neural stem cell self-renewal and differentiation.
Stem Cell Reports 2016 Aug 9;7(2):207-19.
Falk, A., Heine, V.M., Harwood, A.J., Sullivan, P.F., Peitz, M., Brüstle, O., Shen, S., Sun, Y.-M., Glover, J.C., Posthuma, D., Djurovic, S. (2016)
Modeling psychiatric disorders: from genomic findings to cellular phenotypes.
Mol Psychiatry. 2016 Sep;21(9):1167-79.
Heesen, L.*, Peitz, M.*, Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., Jungverdorben, J., Ritzenhofen, S., Weykopf, B., Eckert, D., Hosseini-Barkooie, S.M., Storbeck, M., Fusaki, N., Lonigro, R., Heller, R., Kye, M.J., Brüstle, O.‡, Wirth, B‡. Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cell Mol Life Sci. 2016 May;73(10):2089-104.
Kubaczka, C., Senner, C.E., Cierlitza, M., Araúzo-Bravo, M.J., Kuckenberg, P., Peitz, M., Hemberger, M., Schorle, H. Direct induction of trophoblast stem cells from murine fibroblasts. Cell Stem Cell 2015 Nov 5;17(5):557-68
Gorris, R.*, Fischer, J.*, Erwes, K.L., Kesavan, J., Peterson, D.A., Alexander, M., Nöthen, M.M., Peitz, M., Quandel, T., Karus, M., Brüstle, O. Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia. 2015 Dec;63(12):2152-67.
Ruschel, J., Hellal, F., Flynn, K.C., Dupraz, S., Elliott, D.A., Tedeschi, A., Bates, M., Sliwinski, C., Brook, G., Dobrindt, K., Peitz, M., Brüstle, O., Norenberg, M.D., Blesch, A., Weidner, N., Bunge, M.B., Bixby, J.L., Bradke, F. (2015). Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science 348, 347-352.
Choi, S.H., Kim, Y.H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J.B., Zhang, C., Wainger, B.J., Peitz, M., Kovacs, D.M., Woolf, C.J., Wagner, S.L., Tanzi, R.E., Kim, D.Y. (2014)
A three-dimensional human neural cell culture model of Alzheimer’s disease.
Nature 515(7526):274-278.
Qin, J., Sontag, S., Lin, Q., Mitzka, S., Leisten, I., Schneider, R.K., Wang, X., Jauch, A., Peitz, M., Brüstle, O., Wagner, W., Zhao, R.C., Zenke, M. (2014)
Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells.
Stem Cells Dev 23(23):2875-2882.
Kubaczka, C., Senner, C., Araúzo-Bravo, M.J., Sharma, N., Kuckenberg, P., Becker, A., Zimmer, A., Brüstle, O., Peitz, M., Hemberger, M., Schorle, H (2014)
Derivation and maintenance of murine trophoblast stem cells under defined conditions.
Stem Cell Reports 2(2):232-242.
Peitz, M.*, Münst, B*., Thummer, R.P*., Helfen, M., Edenhofer, F. (2014)
Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.
Stem Cell Res 12(3):680-689
Peitz, M., Jungverdorben, J., Brüstle, O. (2013)
Disease-specific iPS cell models in neuroscience.
Curr Mol Med 13(5):832-841
Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., Kurts, C., Klockgether, T., Neumann, H., Prinz, M., Knolle, P., Klotz, L. (2012)
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by PPARγ.
Brain 135(Pt 5):1586-1605
Koch, P.*, Breuer, P*., Peitz, M.*, Jungverdorben, J.*, Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. (2011)
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
Nature 480:543-546
Hussein, S.M.I., Batada, N., Vuoristo, S., Ching, R.W., Autio, R., Närvä, E., Ng, S., Sourour, M., Hämäläinen, R., Olsson, C., Lundin, K., Mikkola, M., Trokovic, R., Peitz, M., Brüstle, O., Bazett-Jones, D.P., Alitalo, K., Lahesmaa, R., Nagy, A., Otonkoski, T. (2011)
Copy number variation and selection during reprogramming to pluripotency.
Nature 471:58-62
Kuckenberg, P., Peitz, M., Kubaczka, C., Becker, A., Egert, A., Wardelmann, E., Zimmer, A., Brüstle, O., Schorle, H. (2011)
Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.
Mol Cell Biol 31:1748-56
