PD Dr. Michael Peitz
Core Manager
Email: peitz@uni-bonn.de
Tel.: +49-228-6885-156
Cornelia Thiele
Core Technician
Tel.: +49-228-6885-579
Monika Veltel
Core Technician
Tel.: +49-228-6885-547
Science News
- Sedentary Behavior in Mice Induces Metabolic Inflexibility by Suppressing Skeletal Muscle Pyruvate Metabolism April 26, 2024[Journal Of Clinical Investigation] Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.
- Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia April 26, 2024[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.
- Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers April 26, 2024[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.
- YY1 Binding Is a Gene-Intrinsic Barrier to Xist-Mediated Gene Silencing April 26, 2024[EMBO Reports] Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.
- Precise Editing of Pathogenic Nucleotide Repeat Expansions in iPSCs Using Paired Prime Editor April 26, 2024[Nucleic Acids Research] Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.
- BRG1 Programs PRC2-Complex Repression and Controls Oligodendrocyte Differentiation and Remyelination April 26, 2024[Journal of Cell Biology] Scientists demonstrated that Brg1 loss profoundly impaired oligodendrocyte-precursor cell (OPC) differentiation in the brain with a comparatively lesser effect in the spinal cord. Moreover, BRG1 was critical for OPC remyelination after injury.
- Dual-Targeted Novel Temozolomide Nanocapsules Encapsulating siPKM2 Inhibit Aerobic Glycolysis to Sensitize Glioblastoma to Chemotherapy April 26, 2024[Advanced Materials] To effectively inhibit aerobic glycolysis, increase drug delivery efficiency, and improve drug sensitivity, researchers successfully designed and prepared a novel TMZ nanocapsule for the combined delivery of siPKM2 and TMZ.
- Extracellular Vesicles Containing circMYBL1 Induce CD44 in Adenoid Cystic Carcinoma Cells and Pulmonary Endothelial Cells to Promote Lung Metastasis April 26, 2024[Cancer Research] Researchers identified a circRNA derived from MYBL1 pre-mRNA that accompanied overexpression of MYBL1 in adenoid cystic carcinoma (ACC). Overexpression of circMYBL1 was correlated with increased lung metastasis and poor overall survival in ACC patients.
- Regulatory Role of CD39 and CD73 in Tumor Immunity April 26, 2024[Future Oncology] Investigators focus on the role of CD39 and CD73 in immune response and malignant progression, including the expression of CD39 within the tumor microenvironment and its relationship to immune effector cells, and its role in antigen presentation.
- B Cells and Atherosclerosis: A HIV Perspective April 26, 2024[Journal of Cellular Physiology] The authors review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris.