[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.
[Science Immunology] Scientists identified OTULIN deficiency as a cellular condition that licenses RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.
[Cellular & Molecular Immunology] Investigators showed that mice deficient in Zbtb24 in the hematopoietic lineage recapitulated the major clinical features of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome.
[Journal of Clinical Investigation] Researchers demonstrated that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in C1q/TNF related protein 4 (CTRP4)-/- mice compared to WT mice due to increased Th17 cell infiltration.
[Science Advances] Scientists showed that the combination of engineered, tumor matrix-binding IL-7 and IL-12 achieves remarkable anticancer effects by activating complementary pathways without inducing any additive immunotoxicity.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that autoimmunity, caused by conventional T cells expressing constitutively active MALT1 paracaspase, was triggered by cleavage of a single substrate, the RNA-binding protein Roquin-1.
[Journal of Experimental & Clinical Cancer Research] By regulating the mTOR-T-bet axis, ginseng-derived nanoparticles reprogramed macrophages to regulate arginase-1 release, which further ameliorated T cell exhaustion in tumor microenvironment.
[Journal for Immunotherapy of Cancer] Scientists showed that the transfer of G-protein-coupled receptor 84 (GPR84) from myeloid-derived suppressor cells (MDSCs) to CD8+ T cells via the exosomes attenuated the antitumor response.
[Science Signaling] Researchers investigated the mechanisms underlying programmed cell death molecule 1 (PD-1)–mediated inhibition. Their findings suggest an alternative mechanism by which PD-1 regulated immune responses.
[Cell Death & Disease] Investigators revealed that upregulated methyltransferase-like 3 (METTL3) in colorectal cancer exerted both methyltransferase activity-dependent and -independent functions in gene regulation.