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- ATM Knock out Alters Calcium Signaling and Augments Contraction in Skeletal Muscle Cells Differentiated from Human Urine-Derived Stem Cells April 16, 2025[Cell Death Discovery] By using CRISPR/Cas9 technology, the authors knocked out the ataxia telangiectasia mutated (ATM) protein in urine-derived stem cells from healthy donors.
- Novel Directly Reprogrammed Smooth Muscle Cells Promote Vascular Regeneration as Microvascular Mural Cells April 16, 2025[Circulation] Scientists applied myocardin and all-trans retinoic acid with specific culture conditions to directly reprogram human dermal fibroblasts into contractile smooth muscle cells.
- Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis April 16, 2025[Diabetes Care] This was a retrospective cross-sectional analysis of 234 youth with acute recurrent pancreatitis/chronic pancreatitis who had islet Ab testing. Fasting glucose and HbA1c were collected.
- Blocking MSI2 Alleviated Radiation-Induced Pulmonary Fibrosis through Inhibiting Epithelial-Mesenchymal Transition April 16, 2025[International Journal of Radiation Biology] Changes in the expression levels of musashi2 (MSI2) and epithelial-mesenchymal transition markers induced by ionizing radiation in alveolar epithelial cells were detected by western blot.
- RAF1 Promotes Anlotinib Resistance in Non-Small Cell Lung Cancer by Inhibiting Apoptosis April 16, 2025[Journal of Cancer Research and Clinical Oncology] Analysis of RAF1 expression in NSCLC and its relationship with targeted therapy resistance and apoptosis through bioinformatics methods. Immunohistochemistry was employed to evaluate the relationship between RAF1 expression and anlotinib resistance in NSCLC tissues.
- NS3 of Hepatitis C Virus Drives Hepatocellular Carcinoma Progression through a Novel RNA-Interference Pathway April 16, 2025[Journal of Cell Communication and Signaling] Researchers employed transcriptome sequencing to explore the role of non-structural protein 3 (NS3) in promoting HCC progression by comparing gene expression profiles between hepatitis C virus-infected HCC tissues and healthy liver controls.
- BIRC2 Blockade Facilitates Immunotherapy of Hepatocellular Carcinoma April 16, 2025[Molecular Cancer] Genome-wide CRISPR/Cas9 screening was conducted to identify tumor-intrinsic genes pivotal for immune escape. In vitro and in vivo models demonstrated the role of baculoviral IAP repeat-containing protein 2 (BIRC2) in protecting HCC cells from immune killing.
- Chimeric Antigen Receptor-Engineered Cell Membrane-Coated Nanoparticles Promote Dual-Targeted mRNA-Based Cancer Gene Therapy April 16, 2025[ACS Nano ] Researchers demonstrated a CAR-inspired cancer cell membrane-coated platform for delivering an mRNA formulation through a dual tumor-targeted mechanism.
- Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models April 16, 2025[Journal of Clinical Investigation] Scientists investigated the underlying neural mechanisms using several mouse models harboring a gain-of-function B-Raf proto-oncogene (BRAF) mutation discovered in RASopathy patients.
- Differences in chemotherapeutic drug sensitivity before and after patient-derived tumor organoid construction April 16, 2025[Toxicology and Applied Pharmacology] Tumor tissues were divided into two parts: one part was dissociated into a single-cell suspension, and the other part was used to culture tumor organoids.