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Science News
- Tumor-Derived EBV-miR-BART2-5p Promotes Nasopharyngeal Carcinoma Metastasis by Inducing Pre-Metastatic Endothelial Cell Pyroptosis November 18, 2024[Molecular Cancer Research] The authors showed that the expression of pyroptosis-associated proteins was greater in the endothelial cells of metastatic nasopharyngeal carcinoma tissues than in those of nontumor tissues.
- Endothelial Progenitor Cell-Derived Conditioned Medium Mitigates Chronic Cerebral Ischemic Injury Through Macrophage Migration Inhibitory Factor-Activated AKT Pathway November 18, 2024[Stem Cell Research & Therapy] Endothelial progenitor cell-derived conditioned medium was analyzed by cytokine array to identify key factors involved in angiogenesis and cellular senescence.
- N-Acetylneuraminic Acid Triggers Endothelial Pyroptosis and Promotes Atherosclerosis Progression via GLS2-Mediated Glutaminolysis Pathway November 18, 2024[Cell Death Discovery] Researchers constructed GLS2−/−ApoE−/− mice by using HBLV-GLS2 shRNA injection. Immunofluorescence, western blotting, transmission electron microscopy were applied to detect profiles of endothelial injury and atherosclerosis progression.
- Catalpol Regulates Apoptosis and Proliferation of Endothelial Cell via Activating HIF-1α/VEGF Signaling Pathway November 18, 2024[Scientific Reports] Scientists investigated whether Catalpol regulated apoptosis and proliferation following vascular injury induced by burns using an in vitro model of oxygen-glucose deprivation with a HUVEC line.
- Extracellular Vesicles Derived from Endothelial Progenitor Cells Modified by Houshiheisan Promote Angiogenesis and Attenuate Cerebral Ischemic Injury via miR-126/PIK3R2 November 18, 2024[Scientific Reports] Researchers investigated the impact of Houshiheisan-modified xtracellular vesicles-derived extracellular vesicles on angiogenesis using rats with permanent middle cerebral artery occlusion and brain microvascular endothelial cells subjected to oxygen-glucose deprivation.
- SIRT3 Deficiency Promotes Lung Endothelial Pyroptosis through Impairing Mitophagy to Activate NLRP3 Inflammasome during Sepsis-Induced Acute Lung Injury November 18, 2024[Molecular and Cellular Biology] Scientists investigated the effects of sirtuin 3 deficiency on impaired mitophagy to promote lung endothelial cell pyroptosis during sepsis-induced acute lung injury.
- Sandoz Receives European Commission Approval for Afqlir® (Aflibercept), Further Strengthening Leading Biosimilar Portfolio November 18, 2024[Sandoz] Sandoz announced that the European Commission has granted marketing authorization for Afqlir® 2 mg vial kit and pre-filled syringe for intravitreal injection. Afqlir® is indicated to treat various retinal diseases, including neovascular age-related macular degeneration.
- Impairing Ferroptosis through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage November 18, 2024[Cell Biochemistry and Biophysics] In H9C2 cells, exposure to hypoxia for 24 hours led to weakened nerve growth factor level, as well as lowered cell vitality and superoxide dismutase activity, but elevated levels of LDH, Fe2+, malondialdehyde, and reactive oxygen species, triggering ferroptosis.
- Dilated Cardiomyopathy–Associated Skeletal Muscle Actin (ACTA1) Mutation R256H Disrupts Actin Structure and Function and Causes Cardiomyocyte Hypocontractility November 18, 2024[Proceedings of The National Academy of Sciences of The United States of America] The authors demonstrated that a skeletal muscle actin mutation potently caused multiple defects in actin function at the atomic and molecular scales, and it functions in a dominant fashion, leading to cardiomyocyte contractile defects.
- Empagliflozin Attenuates Neointima Formation After Arterial Injury and Inhibits Smooth Muscle Cell Proliferation and Migration by Suppressing Platelet‐Derived Growth Factor–Related Signaling November 18, 2024[Journal of The American Heart Association] Researchers highlighted the crucial role of suppressing platelet‐derived growth factor‐related signaling in mediating the beneficial effects of empagliflozin on neointima formation and vascular smooth muscle cell function, which were independent of sodium-glucose cotransporter 2 and glycemic control.