In addition to the provision of services to members of the Medical Faculty, we also cooperate with other non-profit institutions.
Please contact us for terms and conditions.
Science News
- LINC02257 Regulates Malignant Phenotypes of Colorectal Cancer via Interacting with miR-1273g-3p and YB1 December 19, 2024[Cell Death & Disease] In vitro experiments showed that LINC02257 positively regulated the metastatic and proliferative potential of colorectal cancer (CRC) cells. Mechanistically, LINC02257 affected CRC malignancy by functioning as a competitive endogenous RNA of microRNAs and RNA-binding proteins.
- Development of a Fibrin-Targeted Theranostic for Gastric Cancer December 19, 2024[Science Translational Medicine] Because fibrin is abundant in gastric tumors but not in healthy tissues, researchers hypothesized that fibrin could be used as a high-concentration depot for a high-energy beta-emitting cytotoxic radiopharmaceutical delivered to tumor cells.
- New Therapeutic Approaches for Fibrosis: Harnessing Translational Regulation December 19, 2024[Trends In Molecular Medicine] The authors describe translational regulation in fibrosis and highlight a model where a conserved evolutionary mechanism may explain this regulation.
- PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells December 19, 2024[Oncogene] Investigators uncovered a pivotal role for the arginine methyltransferase PRMT5 in mediating breast cancer stem cells chemoresistance by modulating DNA repair efficiency.
- Inhibition of Glutaminase Elicits Senolysis in Therapy-Induced Senescent Melanoma Cells December 19, 2024[Cell Death & Disease] Scientists demonstrated that glutaminase 1 (GLS1) expression was specifically upregulated in cyclin D1-cyclin-dependent kinases 4 and 6 small molecule inhibitor-induced senescent BrafV600E melanoma cells. Upregulated GLS1 expression rendered BrafV600E melanoma senescent cells vulnerable to GLS1 inhibitor.
- MACC1 Ablation Suppresses the Dedifferentiation Process of Non-CSCs in Lung Cancer Through Stabilizing KLF4 December 19, 2024[Cell Death Discovery] The authors showed that metastasis-associated in colon cancer-1 (MACC1) promoted the transition from non-cancer stem cell (CSC) to CSC in lung cancer.
- Overexpression of ELF3 in the PTEN-Deficient Lung Epithelium Promotes Lung Cancer Development by Inhibiting Ferroptosis December 19, 2024[Cell Death & Disease] Scientists showed that the synergistic role of ELF3 overexpression and PTEN deficiency in driving lung cancer development was highly dependent on the regulation of ferroptosis.
- Time-Efficient Strategies in Human iPS Cell-Derived Pancreatic Progenitor Differentiation and Cryopreservation: Advancing Towards Practical Applications December 19, 2024[Stem Cell Research & Therapy] Researchers differentiated the iPSCs derived from two pediatric Crohn’s disease patients into pancreatic progenitors and exocrine cells, adapting and shortening a protocol for differentiating ESCs.
- Effects of FGFR2b-Ligand Signaling on Pancreatic Branching Morphogenesis and Postnatal Islet Function December 19, 2024[Journal of Molecular Histology] Investigators used an inducible mouse model to control the expression of soluble dominant-negative fibroblast growth factor receptors 2b (FGFR2b) at various stages of pancreatic development.
- Single-Cell RNA Sequencing Identifies Endothelial-Derived HBEGF as Promoting Pancreatic Beta Cell Proliferation in Mice via the EGFR–Kmt5a–H4K20me Pathway December 19, 2024[Diabetologia] The authors analyzed the intracellular and extracellular signaling pathways involved in regulating the physiological proliferation of beta cells using single-cell RNA-seq and in vitro functional assays.