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- Determinants of Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids June 2, 2025[mBio] Investigators followed Salmonella and Shigella infections of human enteroids and colonoids by time-lapse imaging to pinpoint virulence factor modules that shape the divergent epithelial colonization strategies.
- Loss of UBE3A Impacts Both Neuronal and Non-Neuronal Cells in Human Cerebral Organoids June 2, 2025[Communications Biology] scRNAseq on organoids revealed the effects of UBE3A disruption on cell type-specific compositions and transcriptomic alterations.
- Infrequent Strong Connections Constrain Connectomic Predictions of Neuronal Function June 2, 2025[Cell] Scientists characterized the visual responses of 43 cell types in the fruit fly and quantitatively compared them with connectomic predictions.
- Human Endothelial Cells Promote a Human Neural Stem Cell Type B Phenotype via Notch Signaling June 2, 2025[Nature Communications] The authors found that contact with human endothelial cells increases human neural stem and progenitor cell type B cells leading to generation of a human type B single-cell RNA sequencing dataset.
- NEXN Regulates Vascular Smooth Muscle Cells Phenotypic Switching and Neointimal Hyperplasia June 2, 2025[JCI Insight] Using integrative transcriptomics analysis and smooth muscle specific lineage tracing mice, scientists demonstrated NEXN is highly expressed in vascular smooth muscle cells (VSMCs), and the expression of NEXN is significantly reduced during the phenotypic transformation of VSMCs and intimal hyperplasia induced by vascular injury.
- Inhibition of Serotonin-Htr2b Signaling in Skeletal Muscle Mitigates Obesity-Induced Insulin Resistance June 2, 2025[Experimental & Molecular Medicine] Researchers identified the 5-HT receptor 2b (Htr2b) as a critical regulator of insulin sensitivity and energy metabolism in the skeletal muscle.
- GL261 Glioblastoma Induces Delayed Body Weight Gain and Stunted Skeletal Muscle Growth in Young Mice June 2, 2025[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists showed that pediatric brain tumors stunt muscle development in young mice. GL261 glioblastoma cells cause myotube atrophy, reduced carcass, heart, and fat mass, and impeded skeletal muscle growth.
- Efficient and Multiplexed Somatic Genome Editing with Cas12a Mice June 2, 2025[Nature Biomedical Engineering] Investigators generated transgenic mice with Cre-regulated and constitutive expression of enhanced Acidaminococcus sp. Cas12a, which robustly generates compound genotypes, including diverse cancers driven by inactivation of trios of tumour suppressor genes or an oncogenic translocation.
- Intracerebroventricular Bivalent CAR T Cells Targeting EGFR and IL-13Rα2 in Recurrent Glioblastoma: A Phase I Trial June 2, 2025[Nature Medicine] Researchers reported the dose escalation and exploration phases of a Phase I trial investigating intracerebroventricular delivery of bivalent CAR T cells targeting epidermal growth factor receptor (EGFR) epitope 806 and interleukin-13 receptor alpha 2 (IL-13Rα2), or CART-EGFR-IL13Rα2 cells, in patients with EGFR-amplified recurrent glioblastoma.
- Secretion of a VEGF-Blocking scFv Enhances CAR T-Cell Potency June 2, 2025[Cancer Immunology Research] Investigators showed that CAR T cells from patients treated with FDA-approved CAR T-cell products express members of the VEGF signaling pathway and this expression is correlated with patient non-response.