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Science News

• NOR-1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice April 17, 2025
  [FASEB Journal] Transcriptomic profiling of the human response to exercise revealed that the nuclear receptor NR4A3 (NOR-1) was among the most responsive genes to acute exercise.
• One-Step Laser-Assisted Electrohydrodynamic Printing of Microelectronic Scaffolds for Electrophysiological Monitoring of Aligned Cardiomyocytes April 17, 2025
  [ACS Nano ] A laser-assisted electrohydrodynamic printing strategy was proposed to directly fabricate a microfibrous architecture with built-in microelectronics for electrophysiological monitoring of aligned cardiomyocytes.
• Sarcopenia and Skeletal Muscle Loss after CAR T-cell Therapy in Diffuse Large B cell Lymphoma April 17, 2025
  [Clinical Cancer Research] In 83 large B-cell lymphoma patients, the skeletal muscle index was measured from clinical images obtained at baseline and days 30 and 90 post-therapy.
• Insulin Resistance in Type 2 Diabetes Mellitus April 17, 2025
  [Nature Reviews Endocrinology] The authors review established and emerging cellular mechanisms of insulin resistance, their complex integrative features and their relevance to disease progression.
• Pregnane X Receptor Alleviates Sepsis-Induced Liver Injury through Activation of Yes-Associated Protein in Mice April 17, 2025
  [Acta Pharmacologica Sinica] Scientists investigated the role of pregnane X receptor in sepsis-induced liver injury and the underlying mechanisms.
• Chronic Intermittent Hypoxia Alleviates Alcohol-Related Liver Injury via Downregulation of Hepatic Hypoxia-Inducible Factor-2α April 17, 2025
  [American Journal of Physiology-Gastrointestinal and Liver Physiology] As an approach to investigate the relationship between alcohol-enhanced obstructive sleep apnea and alcohol-related liver disease (ALD) development/progression in vivo Gao-binge ALD and chronic intermittent hypoxia mouse models were established.
• Integrated Liver-Secreted and Plasma Proteomics Identify a Predictive Model That Stratifies MASH April 17, 2025
  [Cell Reports Medicine] Researchers assessed plasma and liver from 266 obese individuals spanning the metabolic-associated steatotic liver disease spectrum. Ninety-six human livers were precision-cut, and mass spectrometry-based proteomics identified 3,333 proteins in the liver-secretion medium, of which 107 were differentially secreted in metabolic-associated steatohepatitis (MASH) compared with no pathology.
• HIF-1α/LTBP2 Axis Activate HSCs to Promote Liver Fibrosis by Interacting with LOXL1 via the ERK Pathway April 17, 2025
  [Cellular and Molecular Life Sciences] The authors elucidated the function and mechanism of latent transforming growth factor beta binding protein 2 (LTBP2) in hepatic stellate cells activation and liver fibrosis.
• Gene Therapy Breakthroughs in ALS: A Beacon of Hope for 20% of ALS Patients April 17, 2025
  [Translational Neurodegeneration] The authors summarize the main strategies and techniques of current ALS gene therapies based on ALS risk genes, and review recent findings from animal studies and clinical trials.
• BCMA-CAR T-Cells in a Patient with Relapsing Idiopathic Inflammatory Myositis after CD19-CAR T-Cells April 17, 2025
  [Nature Medicine] Researchers reported on a 45-year-old woman with treatment-refractory Jo-1-associated anti-synthetase syndrome, who initially achieved disease remission after CD19-CAR T-cell therapy but then experienced disease relapse after nine months.