Publications with participation of the Core Facility Analytical Proteomics at the Institute of Biochemistry and Molecular Biology.

2024

  • P. Muller, D. Dietrich, S. Schoch, J. Pitsch, A.J. Becker, S. Cases-Cunillera, Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors, Neurobiol Dis 190 (2024) 106364.

2023

  • C. Yaghootfam, M. Sylvester, B. Turk, V. Gieselmann, U. Matzner, Engineered arylsulfatase A with increased activity, stability and brain delivery for therapy of metachromatic leukodystrophy, Molecular therapy : the journal of the American Society of Gene Therapy (2023).
  • R. Shukla, A.J. Peoples, K.C. Ludwig, S. Maity, M.G.N. Derks, S. De Benedetti, A.M. Krueger, B.J.A. Vermeulen, T. Harbig, F. Lavore, R. Kumar, R.V. Honorato, F. Grein, K. Nieselt, Y. Liu, A. Bonvin, M. Baldus, U. Kubitscheck, E. Breukink, C. Achorn, A. Nitti, C.J. Schwalen, A.L. Spoering, L.L. Ling, D. Hughes, M. Lelli, W.H. Roos, K. Lewis, T. Schneider, M. Weingarth, An antibiotic from an uncultured bacterium binds to an immutable target, Cell 186 (2023) 4059-4073 e4027.
  • S. Schneider, A. Kovacevic, M. Mayer, A.K. Dicke, L. Arevalo, S.A. Koser, J.N. Hansen, S. Young, C. Brenker, S. Kliesch, D. Wachten, G. Kirfel, T. Strunker, F. Tuttelmann, H. Schorle, Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human, Elife 12 (2023).
  • G.E. Merges, L. Arevalo, A. Kovacevic, K. Lohanadan, D.G. de Rooij, C. Simon, M. Jokwitz, W. Witke, H. Schorle, Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis, Development 150 (2023).
  • A.L. Lemster, A. Weingart, J. Bottner, S. Perner, V. Sailer, A. Offermann, J. Kirfel, Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer, Hum Pathol 138 (2023) 1-11.

2022

  • N. Umer, S. Phadke, F. Shakeri, L. Arevalo, K. Lohanadan, G. Kirfel, M. Sylvester, A. Buness, H. Schorle, PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis, Development 149 (2022).
  • A. Rodriguez-Ruiz, D. Braun, S. Pflug, A. Brol, M. Sylvester, C. Steegborn, U. Schweizer, Insights into the Mechanism of Human Deiodinase 1, International journal of molecular sciences 23 (2022).
  • J.A. Muller, J. Betzin, J. Santos-Tejedor, A. Mayer, A.M. Oprisoreanu, K. Engholm-Keller, I. Paulussen, P. Gulakova, T.D. McGovern, L.J. Gschossman, E. Schonhense, J.R. Wark, A. Lamprecht, A.J. Becker, A.J. Waardenberg, M.E. Graham, D. Dietrich, S. Schoch, A presynaptic phosphosignaling hub for lasting homeostatic plasticity, Cell reports 39 (2022) 110696.
  • G.E. Merges, J. Meier, S. Schneider, A. Kruse, A.C. Frobius, G. Kirfel, K. Steger, L. Arevalo, H. Schorle, Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice, Development 149 (2022).
  • W. Jaworek, M. Sylvester, G. Cenini, W. Voos, Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress, J Biol Chem (2022) 102494.
  • L. Wang-Eckhardt, M. Sylvester, I. Becker, J.P. Allam, M. Eckhardt, Citrylglutamate synthase deficient male mice are subfertile with impaired histone and transition protein 2 removal in late spermatids, Biochem J 479 (2022) 953-972.
  • A.K. Gellner, A. Sitter, M. Rackiewicz, M. Sylvester, A. Philipsen, A. Zimmer, V. Stein, Stress vulnerability shapes disruption of motor cortical neuroplasticity, Transl Psychiatry 12 (2022) 91.
  • R.F. Ferreira, T. Blees, F. Shakeri, A. Buness, M. Sylvester, G. Savoini, A. Agazzi, V. Mrljak, H. Sauerwein, Effects of different ratios of omega-6:omega-3 fatty acids in the diet of sows on the proteome of milk-derived extracellular vesicles, J Proteomics (2022) 104632.
  • L.K. Esser, V. Branchi, F. Shakeri, A.G. Simon, C. Stephan, G. Kristiansen, A. Buness, H. Schorle, M.I. Toma, Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels, Int J Oncol 60 (2022).
  • L. de Boni, A.H. Watson, L. Zaccagnini, A. Wallis, K. Zhelcheska, N. Kim, J. Sanderson, H. Jiang, E. Martin, A. Cantlon, M. Rovere, L. Liu, M. Sylvester, T. Lashley, U. Dettmer, Z. Jaunmuktane, T. Bartels, Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by alpha-synuclein conformations, Acta Neuropathol (2022).
  • L. Arevalo, G.E. Merges, S. Schneider, F.E. Oben, I.S. Neumann, H. Schorle, Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice, PLoS Genet 18 (2022) e1010272.

2021

  • L. Martinez-Fresneda, M. Sylvester, F. Shakeri, A. Bunes, J.C. Del Pozo, F.A. Garcia-Vazquez, C. Neuhoff, D. Tesfaye, K. Schellander, J. Santiago-Moreno, ‚Differential proteome between ejaculate and epididymal sperm represents a key factor for sperm freezability in wild small ruminants‘, Cryobiology (2021).
  • M. Khundadze, F. Ribaudo, A. Hussain, H. Stahlberg, N. Brocke-Ahmadinejad, P. Franzka, R.E. Varga, M. Zarkovic, T. Pungsrinont, M. Kokal, I.G. Ganley, C. Beetz, M. Sylvester, C.A. Hubner, ‚Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation‘, Autophagy (2021) 1-17.
  • C. Yaghootfam, B. Gehrig, M. Sylvester, V. Gieselmann, U. Matzner, ‚Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice‘, J Biol Chem (2021) 101064.
  • A. Tuermer, S. Mausbach, E. Kaade, M. Damme, M. Sylvester, V. Gieselmann, M. Thelen, ‚CLN6 deficiency causes selective changes in the lysosomal protein composition‘, Proteomics (2021) e2100043.
  • R.F. Ferreira, T. Blees, F. Shakeri, A. Buness, M. Sylvester, G. Savoini, A. Agazzi, V. Mrljak, H. Sauerwein, ‚Comparative proteome profiling in exosomes derived from porcine colostrum versus mature milk reveals distinct functional proteomes‘, J Proteomics (2021) 104338.
  • K. Pollecker, M. Sylvester, W. Voos, ‚Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation‘, J Biol Chem (2021) 101134.

2020

  • C.A. Bauml, A.A. Paul George, T. Schmitz, P. Sommerfeld, M. Pietsch, L. Podsiadlowski, T. Steinmetzer, A. Biswas, D. Imhof, ‚Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity‘, Eur J Med Chem 201 (2020) 112474.
  • J. Pitsch, D. Kamalizade, A. Braun, J.C. Kuehn, P.E. Gulakova, T. Ruber, G. Lubec, D. Dietrich, R. von Wrede, C. Helmstaedter, R. Surges, C.E. Elger, E. Hattingen, H. Vatter, S. Schoch, A.J. Becker, ‚Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis‘, Annals of neurology 87 (2020) 869-884.
  • S. Schneider, F. Shakeri, C. Trotschel, L. Arevalo, A. Kruse, A. Buness, A. Poetsch, K. Steger, H. Schorle, ‚Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice‘, Cells 9 (2020).
  • A. Zietzer, M.R. Hosen, H. Wang, P.R. Goody, M. Sylvester, E. Latz, G. Nickenig, N. Werner, F. Jansen, ‚The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles‘, J Extracell Vesicles 9 (2020) 1786967.

2019

  • H. Simonis, C. Yaghootfam, M. Sylvester, V. Gieselmann, and U. Matzner, ‚Evolutionary Redesign of the Lysosomal Enzyme Arylsulfatase a Increases Efficacy of Enzyme Replacement Therapy for Metachromatic Leukodystrophy‚, Hum Mol Genet (2019).
  • C. A. Bauml, T. Schmitz, A. A. Paul George, M. Sudarsanam, K. Hardes, T. Steinmetzer, L. A. Holle, A. S. Wolberg, B. Potzsch, J. Oldenburg, A. Biswas, and D. Imhof, ‚Coagulation Factor Xiiia-Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function‚, J Med Chem (2019).
  • L. Schwintzer, E. Aguado Roca, and M. Broemer, ‚Triad3/Rnf216 E3 Ligase Specifically Synthesises K63-Linked Ubiquitin Chains and Is Inactivated by Mutations Associated with Gordon Holmes Syndrome‚, Cell Death Discov, 5 (2019), 75.
  • M. Rausch, J. P. Deisinger, H. Ulm, A. Muller, W. Li, P. Hardt, X. Wang, X. Li, M. Sylvester, M. Engeser, W. Vollmer, C. E. Muller, H. G. Sahl, J. C. Lee, and T. Schneider, ‚Coordination of Capsule Assembly and Cell Wall Biosynthesis in Staphylococcus Aureus‚, Nat Commun, 10 (2019), 1404.
  • W. Rungratanawanich, G. Cenini, A. Mastinu, M. Sylvester, A. Wilkening, G. Abate, S. A. Bonini, F. Aria, M. Marziano, G. Maccarinelli, M. Memo, W. Voos, and D. Uberti, ‚Gamma-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice‚, Nutrients, 11 (2019).
  • C. Schmidtke, S. Tiede, M. Thelen, R. Kakela, S. Jabs, G. Makrypidi, M. Sylvester, M. Schweizer, I. Braren, N. Brocke-Ahmadinejad, S. L. Cotman, A. Schulz, V. Gieselmann, and T. Braulke, ‚Lysosomal Proteome Analysis Reveals That Cln3-Defective Cells Have Multiple Enzyme Deficiencies Associated with Changes in Intracellular Trafficking‚, J Biol Chem (2019).
  • S. Lorscheidt, M. A. Shetab Boushehri, S. Klaschik, and A. Lamprecht, ‚Sub-Cytotoxic Doses of Pharmaceutical Silica Nanoparticles Show Significant Impact on the Proteome of Hepg2 Cells‚, J Control Release, 306 (2019), 1-14.
  • R. Das, L. Schwintzer, S. Vinopal, E. Aguado Roca, M. Sylvester, A. M. Oprisoreanu, S. Schoch, F. Bradke, and M. Broemer, ‚New Roles for the De-Ubiquitylating Enzyme Otud4 in an Rna-Protein Network and Rna Granules‚, J Cell Sci, 132 (2019).
  • Y. Becker, S. Forster, G.H. Gielen, I. Loke, M. Thaysen-Andersen, C. Laurini, K. Wehrand, T. Pietsch, S. Diestel, ‚Paucimannosidic glycoepitopes inhibit tumorigenic processes in glioblastoma multiforme‚, Oncotarget 10 (2019) 4449-4465.
  • D. Massa Lopez, M. Thelen, F. Stahl, C. Thiel, A. Linhorst, M. Sylvester, I. Hermanns-Borgmeyer, R. Lullmann-Rauch, W. Eskild, P. Saftig, M. Damme, ‚The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP‚, Elife 8 (2019).
  • T.S. Wijasa, M. Sylvester, N. Brocke-Ahmadinejad, S. Schwartz, F. Santarelli, V. Gieselmann, T. Klockgether, F. Brosseron, M.T. Heneka, ‚Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer’s disease‚, J Neurochem (2019).

2018

  • M. Crusemann, R. Reher, I. Schamari, A. O. Brachmann, T. Ohbayashi, M. Kuschak, D. Malfacini, A. Seidinger, M. Pinto-Carbo, R. Richarz, T. Reuter, S. Kehraus, A. Hallab, M. Attwood, H. B. Schioth, P. Mergaert, Y. Kikuchi, T. F. Schaberle, E. Kostenis, D. Wenzel, C. E. Muller, J. Piel, A. Carlier, L. Eberl, and G. M. Konig, ‚Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor Fr900359‚, Angew Chem Int Ed Engl, 57 (2018), 836-40.
  • T. Koch, and C. Dahl, ‚A Novel Bacterial Sulfur Oxidation Pathway Provides a New Link between the Cycles of Organic and Inorganic Sulfur Compounds‚, ISME J (2018).
  • J. Schmiesing, S. Storch, A. C. Dorfler, M. Schweizer, G. Makrypidi-Fraune, M. Thelen, M. Sylvester, V. Gieselmann, C. Meyer-Schwesinger, F. Koch-Nolte, H. Tidow, C. Muhlhausen, A. Waheed, W. S. Sly, and T. Braulke, ‚Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity‚, Cell Rep, 24 (2018), 2946-56.
  • A. Wilkening, C. Rub, M. Sylvester, and W. Voos, ‚Analysis of Heat-Induced Protein Aggregation in Human Mitochondria‚, J Biol Chem (2018).

2017

  • M. Bruderek, W. Jaworek, A. Wilkening, C. Rub, G. Cenini, A. Fortsch, M. Sylvester, and W. Voos, ‚Imiq: A Novel Protein Quality Control Compartment Protecting Mitochondrial Functional Integrity‚, Mol Biol Cell (2017).
  • P. Hardt, I. Engels, M. Rausch, M. Gajdiss, H. Ulm, P. Sass, K. Ohlsen, H. G. Sahl, G. Bierbaum, T. Schneider, and F. Grein, ‚The Cell Wall Precursor Lipid Ii Acts as a Molecular Signal for the Ser/Thr Kinase Pknb of Staphylococcus Aureus‚, Int J Med Microbiol, 307 (2017), 1-10.
  • P. Hufendiek, S. S. M. Stolben, S. Kehraus, N. Merten, H. Harms, M. Crusemann, I. Arslan, M. Gutschow, T. Schneider, and G. M. Konig, ‚Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative‚, Planta Med, 83 (2017), 1044-52.
  • A. Papala, M. Sylvester, N. Dyballa-Rukes, S. Metzger, and J. D’Haese, ‚Isolation and Characterization of Human Capg Expressed and Post-Translationally Modified in Pichia Pastoris‚, Protein Expr Purif, 134 (2017), 25-37.
  • W. Peng, W. Grobe, G. Walgenbach-Brunagel, S. Flicker, C. Yu, M. Sylvester, J. P. Allam, J. Oldenburg, N. Garbi, R. Valenta, and N. Novak, ‚Distinct Expression and Function of Fcepsilonrii in Human B Cells and Monocytes‚, J Immunol, 198 (2017), 3033-44.
  • T. S. Wijasa, M. Sylvester, N. Brocke-Ahmadinejad, M. P. Kummer, F. Brosseron, V. Gieselmann, and M. T. Heneka, ‚Proteome Profiling of S-Nitrosylated Synaptosomal Proteins by Isobaric Mass Tags‚, J Neurosci Methods, 291 (2017), 95-100.

2016

  • A. M. Beckmann, K. Glebov, J. Walter, O. Merkel, M. Mangold, F. Schmidt, C. Becker-Pauly, M. Gutschow, and M. Stirnberg, ‚The Intact Kunitz Domain Protects the Amyloid Precursor Protein from Being Processed by Matriptase-2‚, Biol Chem, 397 (2016), 777-90.
  • L. Kaczmarczyk, E. Labrie-Dion, K. Sehgal, M. Sylvester, M. Skubal, M. Josten, C. Steinhauser, P. De Koninck, and M. Theis, ‚New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of Cpeb3 Protein‚, PLoS ONE, 11 (2016), e0150000.

2015

  • A. F. Yassin, C. Sproer, R. Pukall, M. Sylvester, C. Siering, and P. Schumann, ‚Dissection of the Genus Actinobaculum: Reclassification of Actinobaculum Schaalii Lawson Et Al. 1997 and Actinobaculum Urinale Hall Et Al. 2003 as Actinotignum Schaalii Gen. Nov., Comb. Nov. And Actinotignum Urinale Comb. Nov., Description of Actinotignum Sanguinis Sp. Nov. And Emended Descriptions of the Genus Actinobaculum and Actinobaculum Suis; and Re-Examination of the Culture Deposited as Actinobaculum Massiliense Ccug 47753t ( = Dsm 19118t), Revealing That It Does Not Represent a Strain of This Species‚, Int J Syst Evol Microbiol, 65 (2015), 615-24.
  • G. Zocher, J. Vilstrup, D. Heine, A. Hallab, E. Goralski, C. Hertweck, M. Stahl, T. F. Schaberle, and T. Stehle, ‚Structural Basis of Head to Head Polyketide Fusion by Corb‚, Chemical Science, 6 (2015), 6525-36.

2012-2014

  • N. Kamper, S. Franken, S. Temme, S. Koch, T. Bieber, and N. Koch, ‚Gamma-Interferon-Regulated Chaperone Governs Human Lymphocyte Antigen Class Ii Expression‚, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 (2012), 104-16.
  • S. Bremer, K. Klein, A. Sedlmaier, M. Abouzied, V. Gieselmann, and S. Franken, ‚Hepatoma-Derived Growth Factor and Nucleolin Exist in the Same Ribonucleoprotein Complex‚, BMC Biochem, 14 (2013), 2.
  • F. Lohr, I. Jenniches, M. Frizler, M. J. Meehan, M. Sylvester, A. Schmitz, M. Gutschow, P. C. Dorrestein, G. M. Konig, and T. F. Schaberle, ‚Alpha,Beta -> Beta,Gamma Double Bond Migration in Corallopyronin a Biosynthesis‚, Chemical Science, 4 (2013), 4175-80.
  • T. Dodenhof, F. Dietz, S. Franken, I. Grunwald, and S. Kelm, ‚Splice Variants of Perlucin from Haliotis Laevigata Modulate the Crystallisation of Caco3′, PLoS ONE, 9 (2014), e97126.
  • T. Weissgerber, M. Sylvester, L. Kroninger, and C. Dahl, ‚A Comparative Quantitative Proteomic Study Identifies New Proteins Relevant for Sulfur Oxidation in the Purple Sulfur Bacterium Allochromatium Vinosum‚, Applied and environmental microbiology (2014).