Study by the University of Bonn shows that mutations of the investigated gene manifest in different patterns of inheritance The so-called Plexin-A1 gene seems to play a more extensive role in brain development than previously assumed. This is shown by a current study led by the University Hospital Bonn and the Institute of Anatomy of…
Active ingredient inhibits infection with so-called pseudoviruses in the test tube, as shown by study at the University of Bonn Scientists at the University of Bonn and the caesar research center have isolated a molecule that might open new avenues in the fight against SARS coronavirus 2. The active ingredient binds to the spike protein…
Study in Science: Combination of two molecules simultaneously attacks multiple sites on the surface of the virus An international research team led by the University of Bonn has identified and further developed novel antibody fragments against the SARS coronavirus-2. These “nanobodies” are much smaller than the classic antibodies used to treat US President Donald Trump,…
The European Journal of Immunology has published the second edition of the very comprehensive guide to flow cytometry and cell sorting in immunological studies. And we contributed to that edition. Here is the information from the abstract: “These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry…
Recent reports suggest that somatic cell-derived induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons largely preserve age-associated traits such as age-specific DNA methylation patterns, transcriptomic aging signatures and nuclear lamina-associated changes. Michael Peitz, manager of the Cell Programming Core Facility, co-directed a study which adressed a key question: Are age-associated epigenetic and transcriptional…
The European Journal of Immunology has published a very comprehensive guide to flow cytometry in it’s October issue in which we were involved. 231 authors: experts in cytometry & immunology 214 pages 54 sections including: ◦ equipment set-up, data acquisition & handling ◦ barcoding, CyTOF, combinatorial & imaging cytometry ◦ complete immune cell cytometric …
Dowling-Degos disease is a hereditary pigmentation disorder that generally progresses harmlessly. However, some of those affected also develop severe skin inflammation. An international team of researchers under the leadership of the University of Bonn has now found a cause for this link. Their knowledge comes thanks to an animal that is known among aquarium owners…
The Journal of Biological Chemistry, 291, 103-109. The mechanisms of NLRP3 activation are still poorly understood. Jonathan Schmid-Burgk and colleagues present new data on the identification of NEK7, which specifically functions upstream of NLRP3 activation. NEK7 was identified in an unbiased genetic screening approach, which employed the CRISPR technology to identify macrophages that were rendered…
Original published on Phys.org (Phys.org)—A team of researchers with the University of California has learned more about the process that is involved during CRISPR/Cas9 gene splicing by using a crystallization technique to get a closer look. In their paper published in the journal Science, the team describes their study of the way three-stranded structures known…